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For patients planning pregnancy, semaglutide should be discontinued at least 2 months before a planned pregnancy due to the long half-life, while tirzepatide may persist for approximately 1 month

Pancreatitis : In rare cases, GLP-1 medications have been associated with inflammation of the pancreas

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For example: On type 2 diabetes Published in Frontiers in Endocrinology , a 2026 case report by Pendulum researchers describes treatment for a 52-year-old man with a medical history of hypertension and type 2 diabetes mellitus

Urinary tract symptoms : Whilst uncommon, some patients report urinary tract infections or bladder discomfort, though these are not established as direct drug effects of GLP-1 medications