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HendersonSJKonkarAHornigoldDCTrevaskisJLJacksonRFritsch FredinMet al

Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus

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Weight loss failure on tirzepatide usually traces back to insufficient dose (need to escalate further), caloric intake still exceeding expenditure despite reduced appetite, metabolic adaptation, or underlying medical conditions like hypothyroidism or PCOS that require separate treatment