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The average male and female participants in the Surmount 1 study began the protocol with similar baseline BMIs [16], but the female participants lost relatively more weight and had greater health improvements, at least according to BRI, than the male, findings clearly evident from the images shown in Figs
These criteria guide both diagnostic classification and long-term treatment strategies, given the neuroadaptive changes that increase vulnerability to relapse

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If patients experience concerning or persistent injection site reactions, they should discuss these with their healthcare provider rather than assuming such reactions are too minor to report
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