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UK Government and NHS guidance recommends that most adults consider a daily supplement of 10 micrograms (400 IU) of vitamin D, particularly during autumn and winter months when sunlight exposure is limited

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An earlier version incorrectly stated that in 2020, the total combined direct cost of overweight and obesity in South Africa was estimated to exceed R33 million

This aligns with broader MedTech trends toward value-based care and patient-centric solutions.13 For Aesthetic Practitioners Medspas are leading adoption with 60% offering GLP-1 services compared to 35% of physician offices, indicating the importance of accessible, consumer-friendly treatment environments.17 The integration of holistic and integrative approaches emphasizing nutrition, mental health, and lifestyle factors alongside aesthetic treatments represents a competitive advantage
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In conclusion, the GLP-1/GLP-1R signalling plays a significant role in the balance of innate immunity, particularly in the polarisation of macrophages
