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Its this durability, which allows it to persist in far greater concentrations than GLP-1 in our bodies, even when were resting, that makes semaglutide so much more potent than the hormone by itself, explained Gregory Steinberg, the Canada Research Chair in metabolism and obesity and co-director of McMaster Universitys Centre for Metabolism
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The increase in glucose levels after food intake decreases the activity of AMPK and, conversely, the activity of the mTOR/S6K1 pathway is stimulated by higher levels of glucose and amino acids

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