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Published data (SURMOUNT-4 trial) show most patients regain a meaningful portion of lost weight after discontinuation

Patients should be counseled about symptoms of MTC, including neck mass, dysphagia, dyspnea, or persistent hoarseness, and to seek prompt medical evaluation if these occur

The choice between them should be based on the GLP-1 agonist comparison, not the levocarnitine addition

Increase fluid intake to maximum tolerable levels

For patients already managing multiple daily medications, once-weekly injection of tirzepatide can be more convenient and easier to use on a long-term basis

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