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Functional analyses demonstrated that i ) DIV-1 is required for the robust proliferation typical of the germline, ii ) loss of DIV-1 enhances and suppresses specific phenotypes that are associated with reduced and elevated GLP-1/Notch activity in germline and somatic tissues, and iii ) DIV-1 works together with FBF/PUF proteins, downstream regulators of GLP-1/Notch signaling, to promote germline stem cell (GSC) maintenance and germline proliferation

Introduction: Obesity is a global epidemic affecting 2.5 billion people and is recognized as the fourth leading cause of global mortality

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These GLP-1 receptor agonists offer impressive health benefits, from better blood sugar control to significant weight reduction

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