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Liraglutide : In a 56-week study, people taking the highest dose of liraglutide 3 mg, the maximum approved dose for Saxenda , lost an average of 8% of their body weight

Sources: Hussein RS et al

Symptom #5: Fatigue and Low Energy Some people report feeling more sluggish or fatigued after stopping semaglutide

Surgical options: In severe cases, surgery to remove lesions might be required

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Another 2025 survey published in JAMA Health Forum noted that, should Medicare pay for the drugs, it could avoid spending a hypothetical $18.2 billion on obesity-related health expenditures over 10 years while dishing out $65.9 billion annually on the GLP-1s by year 10, thereby negating any savings