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These results suggest that the endogenous relevance of LHA GHSR signaling to palatable food-motivated responding is more prominent in females, whereas the opposite is true for LHA GLP-1 signaling

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If the JCAs PICO-defined comparator doesnt match the trial design, the relative effectiveness assessment may be inconclusive or negative not because the drug doesnt work, but because the trial wasnt designed to answer the JCAs specific question