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The assessment of TEAE severity was based on the Amgen standard grading scale as follows: mild (aware of symptom, but easily tolerated), moderate (discomfort enough to cause interference with usual activity) and severe (incapacitating with inability to do work or do usual activity)
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To further assess the adverse profile of GLP-1MK-801, we performed a series of complementary studies in mice and rats
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Despite the species differences, the FDA maintains a boxed warning for these compounds
Lane-Donovan C, Philips GT, Herz J
