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doi: 10.1038/npp.2016.143 60 FletcherJ

We and others previously demonstrated GDF8 and ActA are the two major ligands which mediate the muscle minimization actions of the ActRIIA/B receptors in non-obese mice and NHPs 22,28,30 , and we have further shown that dual blockade of GDF8 and ActA led to much larger increases in muscle mass than blocking either ligand individually, and that dual blockade matched the muscle growth actions of broader ActRIIA/B blockade 28 , similar to effects seen when using a dominant-negative type II receptor or pro-domains of GDF8 and activins 22,26,27

Gutin said that though the restaurant is not known for very big portions, this new section of the menu caters to people who want to eat less, even if they are not taking weight-loss drugs, like older adults or people who just want smaller meals

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For example, it includes making food cues more powerful in encouraging overeating, a phenomenon known as incentive sensitization (being extra sensitive to rewards)