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The UK Medicines and Healthcare products Regulatory Agency issued a reminder in 2024 that health professionals should be making patients aware of the known side effects of GLP-1RAs, and reiterated the need for ongoing monitoring

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GLP-1 receptors in the brain The brain contains abundant GLP-1 receptors in key regions including the hippocampus, cerebral cortex, hypothalamus, thalamus, and globus pallidum 26

The more someones situation resembles the clinical population, with substantial excess body fat and difficulty controlling intake, the stronger the evidence base