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Well also have far more information about its long-term safety profile, which can only be a good thing.

Lofton, some patients are super responders and experience benefits even at reduced doses

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Efficacy of adjunctive high frequency repetitive transcranial magnetic stimulation of right prefrontal cortex in adolescent mania: A randomized sham-controlled study

And three, I would say that these medications are powerful metabolic tools, but they're not replacements for disease-modifying anti-rheumatic drug therapy, and further prospective trials are needed to define their role in rheumatology