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however, there were no significant differences observed in the outcomes of requiring amputation and revascularization

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Clinical trials show that without ongoing treatment or lifestyle intervention, patients may lose 50-70% of the weight they initially dropped

Contemporary evidence has established a clear efficacy hierarchy among agents, with dual and triple receptor agonists demonstrating superior outcomes compared to traditional GLP-1 monotherapy (Table 4)

doi:10.1186/1475-2840-13-80
As more clinical data demonstrates that GLP-1 medications produce sustained weight loss and reduce obesity-related comorbidities, coverage is expanding
