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In contrast, two studies, including 41,046 exposed pregnancies and 131,407 comparator pregnancies, identified a statistically significant association with urinary congenital malformations (OR 1.24

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Drugs affecting gastric emptying or those requiring specific timing relative to meals may need adjustment

In the SELECT trial, it also significantly reduced major adverse cardiovascular events among high-risk patients without diabetes, leading to an indication for cardiovascular risk reduction

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