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In November 2023, the US pharma giant received FDA authorization for Zepbound under the trade name Mounjaro (both tirzepatide), and the drug produced $176 million in revenue over six weeks in 2023

(2022) Efficacy of once-weekly tirzepatide versus once-daily insulin degludec on glycaemic control measured by continuous glucose monitoring in adults with type 2 diabetes (SURPASS-3 CGM): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Moderate or Severe Renal Impairment: observations From the SAVOR-TIMI 53 Trial

Both conditions stimulate the release of pro-inflammatory molecules, making them potential targets for biological medications, like Infliximab or Humira which aim to calm down the immune response (4)

Effect of aging on gallbladder contraction and release of cholecystokinin-33 in humans

The use of this drug is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome 2