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doi: 10.1210/clinem/dgaa327 31 NovikoffAOBrienSLBerneckerMGrandlGKleinertMKnerrPJet al
The clinical evidence establishes unprecedented therapeutic efficacy across established indications, with newer multi-receptor agonists achieving HbA1c reductions exceeding 2.0% in diabetes, weight loss approaching 24% in obesity that rivals bariatric surgery outcomes, and cardiovascular protection demonstrating consistent 1420% MACE reduction with emerging benefits in heart failure with preserved ejection fraction
When combined with GLP-1 RAs, these effects may be amplified, potentially enhancing compliance and sustainability (Fig
Many people want more mild and subtle flavors, says Vanessa Bailey, senior manager, global strategy and innovation, healthful solutions, at Ingredion
However, microdosing is typically considered to be safe as it involves very small or fractional doses of medications
