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Conclusions The treatment of patients with HFpEF and obesity with tirzepatide produced a broad spectrum of large and clinically meaningful benefits on the trajectory of HF, evident across multiple domains and including improved health status and well-being, enhanced functional capacity and exercise tolerance, reduced symptom and medication burden, and prevention of worsening HF events

The drug levels of medications with narrow therapeutic windows (i.e

Use over-the-counter remedies for constipation or diarrhoea if needed

Renal function should be monitored, especially if patients experience significant gastrointestinal symptoms that could lead to dehydration

The practical implication for researchers is that tirzepatide protocols often produce more pronounced metabolic effects than equivalent semaglutide protocols, which the semaglutide versus tirzepatide comparison documents in detail