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The primary endpoint was change in A1C from baseline at 26 weeks

Novo's earnings miss in February, which triggered a 13.8% one-day drop, was the first signal that momentum had reversed

The proposed model is largely based on in vitro experiments and is not directly translatable to in vivo settings

A 2024 study published in JAMA Ophthalmology reported that patients with Type 2 diabetes who took semaglutide-containing medications had more than a fourfold higher risk for developing non-arteritic anterior ischemic optic neuropathy (NAION) compared with patients not on a GLP-1 agonist

doi: 10.1056/NEJMoa1911303 63 PackerMAnkerSDButlerJFilippatosGPocockSJCarsonPet al

Those details matter