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some preclinical and early research has suggested possible expression in skin-associated cells, though this evidence is not yet well established in humans and should be regarded as hypothesis-generating rather than confirmed

Medical practices should develop comprehensive materials explaining common reactions and management strategies

[1] [4] In the NHS, Wegovy is typically prescribed through specialist weight management services (Tier 3) in accordance with NICE guidance and local commissioning arrangements

Possible Pancreatitis Risk There have been concerns about pancreatitis (inflammation of the pancreas)

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In people with obesity, 36 weeks of orforglipron (doses ranging from 12 to 45 mg in a phase 2 trial) resulted in a dose-dependent WL up to 14.7% compared to 2.3% with placebo, with concomitant improvement in cardiometabolic risk factors (Table 2) [25]