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Those included: Nausea (about 29 to 42 percent of participants, depending on the dose) Diarrhea (25 to 34 percent) Constipation (24 to 26 percent) Vomiting (11 to 25 percent) Upper respiratory tract infection (12 to 14 percent) Interestingly, more people taking a placebo dropped out of the trial because of side effects than participants taking the lowest dose of retatrutide (4.9 percent compared with 4.1 percent)

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Phase 3 weight loss approximately 22.5%

They point to research done in rodents related to nicotine addiction

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