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The result is a catch-22: patients must persist long enough to demonstrate clinical benefit, yet the financial burden often prevents that persistence, undermining the very outcomes needed to justify reimbursement

In addition, we extracted the type, dose, route, duration, and outcomes of GLP-1 administration

Melissas J, Koukouraki S, Askoxylakis J, Stathaki M, Daskalakis M, Perisinakis K, Karkavitsas N

Unlike weight loss medications developed specifically for metabolic disease, semaglutide's interaction with enteric neurons and intestinal smooth muscle suggests a direct relationship with IBS symptomsthough clinical outcomes vary significantly between individuals