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Trial registrations ClinicalTrials.gov identifiers: NCT02054897, NCT01930188, NCT01885208, NCT02128932, NCT02305381, NCT01720446, NCT02207374, NCT02254291, NCT02906930, NCT02863328, NCT02607865, NCT02863419, NCT02827708, NCT02692716, NCT02849080, NCT03021187, NCT03018028, NCT03015220.

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Vaccines, monoclonal antibodies, and peptide-based treatments must be carefully evaluated to avoid triggering similar cross-reactions

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The same framework that predicts AD efficacy also predicts GI tolerability: the calcium signaling network operates in both brain and gut, with the same proteins producing opposite clinical consequences in different tissues