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doi: 10.1172/JCI25764

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News Large-scale analysis of more than 400,000 Reddit posts has identified patient-reported symptoms associated with glucagon-like peptide-1 receptor agonists that may not be fully captured in clinical trials, with reproductive and temperature-related effects emerging as signals for further investigation in real world evidence A research team at the University of Pennsylvania, Philadelphia, USA, has used artificial intelligence to analyse more than 400,000 Reddit posts and identified patient-reported symptoms associated with glucagon-like peptide-1 (GLP-1) receptor agonists that may not have been explored in randomised clinical trials (RCTs) or regulatory documentation

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However, in a Crohns disease pilot trial, VNS restored a homeostatic vagal tone, and reduced inflammation via increase of anti-inflammatory TGF- and decrease of proinflammatory factors (Sinniger et al