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Clinical indications and expanding use Following fluoxetine, several SSRIs (e.g., sertraline, citalopram, and escitalopram) were introduced and are now established as first-line pharmacotherapies for major depressive disorder (MDD) and many anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder) [6]

Panel b : The percentage of participants reaching weight-reduction thresholds at Week 72 is calculated using logistic regression with mixed model repeated measures for missing data imputation using an efficacy estimand