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Lam CSP, Ferreira JP, Pfarr E, Sim D, Tsutsui H, Anker SD, et al

Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain

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WCG Institutional Review Board (Cary, NC, USA) granted a waiver exemption for this study from full institutional review board review

The Wegovy-vs-Zepbound gap is consistent with mechanism: Wegovy activates only the GLP-1 receptor at a high obesity-management dose, while tirzepatide adds GIP receptor activity that may modestly buffer some GI effects
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