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Executive Vice President of R&D James Bradner doubled down on this position, when an analyst brought up that more convenient schedules could come at the cost of weaker weight loss outcomes

A large comparative-effectiveness study published in JAMA Internal Medicine analyzed approximately 36,000 patients on SGLT2 inhibitors versus 19,000 on GLP-1 receptor agonists in Denmark (Jensen et al., 2026)
Awareness of GLP-1 hormones exploded thanks to the rise of prescription medications like semaglutide and tirzepatide

Villaschi A, Ferrante G, Cannata F, Pini D, Pagnesi M, Corrada E, Reimers B, Mehran R, Federici M, Savarese G et al

However, always inform your prescriber about all medications you are taking, including semaglutide

Newer agents appear to be more effective at A1c and weight lowering, and its a very exciting time for the treatment of type 2 diabetes and obesity when the new GLP-1 agonists are able to achieve more robust A1c lowering than any other existing diabetes medication other than insulin, she told Healthline
