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GLP-1 also blocks glucagon secretion

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[DOI] [PMC free article] [PubMed] [Google Scholar] 68.D'Abbondanza M., Ministrini S., Pucci G., et al

Retatrutide clinical trial results The phase 2 trial, published in the New England Journal of Medicine, tested retatrutide at doses ranging from 1 mg to 12 mg weekly in adults with obesity

These may include: Nausea, vomiting or diarrhoea (most common early on) Constipation Fatigue Mild increases in heart rate (similar to changes seen with GLP-1 medicines) Side effects were more frequent at higher doses (8 mg and 12 mg), but still rated mild to moderate overall

Also, due to the important role of endothelial dysfunction in CVD, the effects of GLP-1RA on flow-mediated vasodilation (FMD) in patients remain to be investigated for their contribution to the CVD actions of GLP-1RAs