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These data are consistent with the T allele decreasing risk for T2D, as well as decreasing glucose and HbA1c levels, but slightly increasing the risk of smoking initiation (Supplementary Table 16)

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10.1210/jc.2009-0921 87

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Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial