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Description
Localization of orexins-1 receptors to vagal afferent neurons in the rat and humans

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The titration schedule used in clinical trials (slow, stepwise dose increases over multiple weeks) is specifically designed to minimize the intensity of these early side effects

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In both studies, participants lost around 20% of their body weight Current treatments for sleep apnea target the symptoms of this condition stopped breathing but tirzepatide addresses the underlying cause, blockages in the airway that result in breathing pauses during sleep