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By the time the next dose increase occurs, many patients have adapted to the current dose and the cycle begins again at a manageable level

Additionally, Abdullah says that you should never freeze GLP-1 medications, because freezing can denature the peptides (that is, unravel the active ingredient), potentially rendering the medication ineffective

Efficacy and Bone Safety of Sotagliflozin 400 and 200 mg Versus Placebo in Participants with Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control (SOTA-BONE) [(accessed on 28 October 2024)]

The drugs can also reduce the effectiveness of some forms of birth control, making unplanned pregnancies more likely

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