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Absolute contraindications to GLP-1 receptor agonists with the boxed warning include patients with a personal history of MTC, family history of MTC, or known MEN 2 syndrome

Tirzepatide is the first in a class of drugs called dual GLP-1/GIP receptor agonists that activate the receptor for another gut hormone, glucose-dependent insulinotropic polypeptide (GIP), in addition to the GLP-1 receptor

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GLP-1-induced weight loss directly translates to reduced joint stress, slowing cartilage degradation and improving mobility

The safety and efficacy of oral semaglutide has not been compared to injectable semaglutide in a head-to-head clinical trial, a Novo Nordisk spokesperson told Scientific American

The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review