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They found rapid weight loss was followed by a rapid rebound

How Rapid Weight Loss Differs From Gradual Weight Loss, Biologically I think it is worth explaining directly why the speed of weight loss appears to matter so much for skin outcomes, since this is a detail that gets glossed over in a lot of general reporting

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We know from experience that a lot of times they're still going to need a breast reduction, so it's chicken or the egg in that situation

Additionally, GLP-1 receptor agonists may exert direct anti-inflammatory effects on hepatic tissue, though the clinical significance of these direct effects remains under investigation