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[DOI] [PMC free article] [PubMed] [Google Scholar] 10

In animal models, GLP1 receptor activation has been linked to increased neurogenesis and enhanced synaptic plasticity

doi: 10.2337/db13-0227

Zhang L, Yang M, Ren H, Hu H, Boden G, Li L, et al

Lastly, although many of the beneficial effects attributed to GLP-1 RAs are inferred from established molecular pathways or disease surrogates, it is essential to distinguish between weight-lossmediated and weight-independent geroscience effects

In fact, as outlined above, HF is even more prevalent amongst people with obesity than amongst those with type 2 diabetes, and the consequences of excess body weight (i.e., adipose tissue) most likely play direct and indirect key roles in the development of HF