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Alcohol- and other substance-use disorders may well benefit from the effects of GLP-1RAs on dopamine and opioid pathways that are dysregulated in addiction 243 , as seen in some of the studies we identified, and the same could also apply to other under-investigated disorders with similar underlying dysfunctions (for example, gambling disorder)

Initially, it was a modest tool in the diabetes arsenal: enhanced insulin release, suppressed glucagon, slowed gastric emptying

doi: 10.1016/S1875-5364(22)60196-1

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However, clinical outcomes have been variable, highlighting the need for optimized trial designs, improved biomarkers, and patient stratification