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FOR SEVERE DEHYDRATION SOURCE: Patricia N

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(2010) Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening

Indeed, a monomeric peptide with potent and balanced triple agonism of GLP-1R, GIPR, and GcgR induced greater body weight loss than the respective co-agonists and mono-agonists in obese mice [466]

References 1.Loos R.J.F., Yeo G.S.H

Better understanding the development/maintenance of GLP1 neurons, combinatorial therapy involving GLP1 designer agonists, as well as the acute versus chronic effects of GLP1 on the brain will undoubtedly be growing areas of study to better understand the therapeutic benefits of this system in metabolic disease