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Dysregulated insulin, cortisol, thyroid hormones, and leptin can also make it difficult to lose visceral fat
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In comparison, a small molecule like orforglipron is a roughly 16-step convergent organic synthesis from common starting materials (see, e.g., Part I and Part II of a key intermediate synthesis from the Lilly process team)

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Vivier E, Rebuffet L, Narni-Mancinelli E, Cornen S, Igarashi RY, Fantin VR
