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Cannabinoid receptor 1 (CB1R) is expressed in presynaptic and postsynaptic neuronal sites in the lateral habenula, where they modulate behavioral responses to stress exposure, such that CB1R blockade reduced anxiety-like behaviors [50] and also in GABAergic cells in the ventral tegmental area (VTA) and their stimulation increases firing of dopamine neurons, which modulate reward [51]

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[2] While topiramate can cause weight loss as a side effect, using it primarily for weight management is considered off-label in the UK and should only be considered under specialist care when indicated for its licensed uses

Pfizer said it tested four formulations of the drug to determine which might be most effective, but didnt disclose which worked best, just saying one showed the most favorable profile. Candidly, todays trial never answered the question on what once-daily modified release dose would get to competitive efficacy, Raffat said in a note to investors