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However, at closer inspection, these reactions were more likely caused by the (concomitant) use of angiotensin-converting enzyme inhibitors or an infection (130)

GLP-1 RA can suppress appetite, delay gastric emptying, reduce plasma glucose levels and enhance insulin secretion in order to regulate glucose levels

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And adequate hydration mitigates several common side effects

The combination of both is what most successful tirzepatide users rely on to eliminate heartburn entirely