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Indication and Usage RYBELSUS (semaglutide) tablets 7 mg or 14 mg is indicated: as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes mellitus who are at high risk for these events Important Safety Information for RYBELSUS WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

(Table 3) Conclusion: In obese, non-diabetic RA patients, GLP-1 RA therapy significantly reduced one-year all-cause mortality and cardiovascular events, particularly heart failure

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Patients with diabetes require additional monitoring for retinopathy and hypoglycemia, especially if taking insulin or sulfonylureas

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Approximately 16 million adults 6% of the US population are currently taking GLP-1s, which have proven effective in managing diabetes and helping people lose an average of 15% of their body weight