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Treatment choices require individual tradeoffs The authors conclude: Treatment decisions for obesity should be individualized, balancing expected benefits, harms, treatment burden, costs, availability, and patient preferences. Researchers writing in a linked editorial said the comparison provides useful information for conversations between patients and clinicians as the number of obesity treatment options continues to expand

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489 Microglia-targeted therapies in clinical trials for PD The recruitment for the phase 1 trial of inzomelid, a promising NLRP3 inhibitor, was completed in 2020 (NCT04015076), but results have not yet been disclosed