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While semaglutide should be safe for most people, it often causes gastrointestinal side effects early in treatment, including:8 Bloating Abdominal pain Nausea Vomiting Diarrhea Belching Flatulence While these arent the most pleasant or flattering side effects, they often fade with use as your body adjusts to the effects of the medication

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Indeed, nutrient infusions directly into the ileum cause significantly greater increases in portal vein (the major blood vessel that collects intestinal secretions) concentrations of GLP-1 (90)