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Teplizumab is approved in the United States for stage 2 type 1 diabetes in individuals aged 8 years and older [99,100], and has been found in a systematic review to slow progression of C-peptide loss in recently diagnosed stage 3 type 1 diabetes [101]

The mechanism is tied to glucagon receptor activation, which has a direct stimulatory effect on the sinoatrial node in the heart

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Semaglutide treatment in our case series of patients with PWS without diabetes led to weight reduction and/or weight maintenance, as well as to appetite suppression as reported by patients and caregivers