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These risks and uncertainties include, but are not limited to, those factors described in the Risk Factors section of each of our most recently filed Quarterly Report on Form 10-Q, our most recently filed Annual Report on Form 10-K, and any of our subsequent filings with the Securities and Exchange Commission (the Commission)

In summary, depressive diseases correspond to somatic and cognitive alterations principally including sadness, empty moods, irritability, or anhedonia

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These are among the leading causes of preventable, premature death, leading many medical practitioners to call the rise in obesity a global health crisis

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Circulation 141 , 940942 (2020)