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A comprehensive meta-analysis of 47 randomized, controlled trials encompassing more than 23,000 participants found that GLP-1 receptor agonists led to significant reductions in body weight, body mass index (BMI) and waist circumference compared to placebo
Translation: consistency is the mechanism

- Enhances peripheral glucose uptake and utilization
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But that accelerated weight loss creates nutritional challenges that most prescribers never discuss