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GLP-1 medicines are not primarily cleared by the kidneys, but the gastrointestinal side effects (nausea, vomiting, and reduced fluid intake) can cause dehydration that may strain the kidneys or trigger acute kidney injury, so staying well hydrated is important

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The Role of Diet During Semaglutide Use Foods high in fermentable carbohydrates, sugar alcohols, and certain fibers can amplify gas while your digestive system adapts
Many gastrointestinal side effects may decrease as treatment continues, but there is no guaranteed week when they disappear

As key patents for leading products (such as semaglutide and tirzepatide) approach expiration in various countries, a new wave of companies, ranging from traditional generics manufacturers to complex peptide manufacturers and hybrid developers, is preparing to enter the market
