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3.4 Tirzepatide effects: adverse effects of tirzepatide Gastrointestinal adverse effects of tirzepatide are similar to GLP-1 RAs, which include nausea and vomiting likely caused by the appetite-suppressing mechanism of incretins [47]

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Glucose-dependent insulinotropic polypeptide suppresses foam cell formation of macrophages through inhibition of the cyclin-dependent kinase 5CD36 pathway