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Tirzepatide is a dual agonist that targets glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

Klausen et al 37 reported adverse effects related to GI symptoms, body weight loss, fatigue, and injection site reactions, and the incidence was higher in the exenatide group compared with the placebo group

The most pronounced benefit was observed for nonfatal stroke, with a 32% risk reduction [I 2 = 0%, HR 0.68, 95% CI (0.56, 0.83)

Overall, the addition of L-81 to Liposyn did not reduce the cumulative GLP-1 output to the same levels as saline controls, whereas GIP secretion was abolished (Lu et al., 2012)
