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A recent review in Diabetes Care evaluates the efficacy and safety of GLP-1 receptor agonists for type 2 diabetes and obesity, exploring their potential for new medical indications.

Given that the Mounjaro rollout plans for primary care physicians to be prescribers, there is a huge awareness challenge to be overcome, and very rapidly

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GLP-1 medications like semaglutide work through a different pathway to reduce appetite and support weight loss

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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems