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Risks associated with oral semaglutide and GLP-1 pills include gastrointestinal symptoms, gallbladder issues, and rare cases of pancreatitis

Guirguis says combination treatments such as this could offer additive or synergistic effects meaning that patients have a better chance of responding to at least one of the mechanisms and could experience fewer GI side effects as a result of the dual approach

10.1056/NEJMoa030204 14 BerthoudH

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SUSTAIN-6 (Semaglutide in Subjects with Type 2 Diabetes) was the next trial published, lending credence to the cardiovascular benefits of semaglutide

Bassi M, Singh S